1-Propionyl-d-lysergic acid diethylamide (also known as 1P-LSD) is a semi-synthetic psychedelic substance of the lysergamide class.
1P-LSD is closely related to LSD and is reported to produce near-identical effects.
There is little known about the pharmacology of 1P-LSD, but it likely produces its psychedelic effects by acting on serotonin receptors in the brain.
The original synthesis date of 1P-LSD is unknown. Unlike most research chemicals, 1P-LSD has no prior record in the scientific literature. The first reports of 1P-LSD use surfaced in 2015 following its appearance on the online research chemical market. Resulting it was marketed as a legal alternative to LSD alongside other novel lysergamides like ALD-52, ETH-LAD, and AL-LAD.
User reports indicate that the subjective effects of 1P-LSD are extremely similar to those of LSD. 1P-LSD is theorized to act as a prodrug for LSD.
The similarities in chemical structure between 1P-LSD and LSD predicts a near-identical effect profile, likely differing mainly in its rate of absorption and duration. Characteristic effects include geometric visual hallucinations, time distortion, enhanced introspection, and ego loss. Its classical psychedelic effects and favorable tolerability has led it to become popular among novel psychoactive substance users who use it interchangeably with LSD.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 1P-LSD. It is presumed to have a similar toxicity and risk profile as LSD, although no evidence currently exists to support this. It is highly advised to use harm reduction practices if using this substance.
|Substitutive name||1-Propionyl-d-lysergic acid diethylamide|
|Light||25 – 75 µg|
|Common||75 – 150 µg|
|Strong||150 – 300 µg|
|Heavy||300 µg +|
|Total||8 – 12 hours|
|Offset||3 – 5 hours|
|After effects||6 – 24 hours|
1P-LSD is a semisynthetic compound of the lysergamide family. It is similar to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD. Propionyl consists of the carbonyl chain CH3CH2CO- bound to an amino group. Likewise, it is homologous to ALD-52, which holds an acetyl group bound to the nitrogen instead of the propionyl group bound at the same location.
The structure of 1p-lsd contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group. At carbon 8 of the quinoline, an N,N-diethyl carboxamide is bound.
What are NBOMes?
NBOMes is the name for a series of drugs that have hallucinogenic effects. Reports indicate that there are a number of different versions of NBOMe available – all with differing effects.
Psychedelics change the way a person perceives the world and can affect all the senses, altering a person’s thinking, sense of time and emotions.
NBOMe drugs are also referred to as a New Psychoactive Substances (NPS) because they are designed to mimic or produce similar effects to common illicit drugs such as LSD.
Other names for NBOMes
N-Bomb, Bom-25, 2C-I-NBOMe, 25-I-NBOMe, 25I, Pandora, Solaris, Divination, wizard and Smiley Paper.
25-I-NBOMe is not the same as 2C-I, however. It is important they are not confused because 25-I-NBOMe is a lot stronger and the effects are felt when only a very small amount is taken. It is therefore much easier to overdose after using 25-I-NBOMe.
There have been reports that NBOMes have also been included in some ecstasy pills.
Other types of commonly used psychedelics
What do they look like?
NBOMes can be in the form of blotting paper (similar to LSD) with images and logos from popular culture, clear liquid, white powder or a pill. NBOMes have a very bitter taste whereas LSD has no taste.
How are they used?
It was originally thought that 25I-NBOMe was inactive if swallowed, however there have been reports of overdoses occurring after oral administration. As a result the most common methods of taking NBOMe are under the tongue, held in the cheek or snorted.
Effects of NBOMes
There is no safe level of drug use. Use of any drug always carries some risk – even prescribed medications can produce unwanted side effects.
Low to moderate doses of NBOMes can produce effects that last between 4 – 10 hours.
NBOMes affects everyone differently, but reported effects have included:
- seeing and hearing things that aren’t there
- feeling happy and relaxed
- heightened senses (sight, hearing and touch)
- increased sex drive
- feelings of empathy
- large pupils
- memory lapses
- facial flushing, chills, goose bumps
- small increase in heart rate.
If you take a large amount or have a strong batch, you might overdose. Because of that, in any event you need to call an ambulance straight away by dialing triple zero (000) if you have any of these symptoms. Moreover, ambulance officers don’t need to involve the police.
- difficulty communicating
- restless sleep and exhaustion
- paranoia, fear and panic
- agitation and aggression
- rapid spasms in the eye
- difficulty urinating
- rapid heart rate
- rapid or difficulty breathing
- overheating (hyperthermia)
- numbness and swelling of feet, hands and face
- blue fingers and toes
There have also been reports of deaths as a result of car accidents, suicide and drownings.
Using an NBOMe carries a high risk of overdose due to the small difference between the amount required to produce a high and that which causes overdose. Not knowing the amount contained in the tablet or blotter increases the risk of overdose as it’s easy to take too much.
The use of NBOMes is relatively new, hence long term effects have not yet been established.
Taking NBOMe’s with other drugs
The effects of mixing an NBOMe with other drugs, including alcohol, prescription medication and over-the-counter medicines are not known. However, reports of people attending emergency departments after taking an NBOMe demonstrate that alcohol and other drugs may contribute to overdose effects.
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