25N-NBOMe (2C-N-NBOMe) is a derivative of the substituted phenethylamine psychedelic 2C-N which was discovered in 2004 by Ralf Heim at the Free University of Berlin and subsequently investigated by a team at Purdue University led by David Nichols.
25N-NBOMe has a notably shorter duration than the rest of the 25x-NBOMe series, with a total duration of 6 hours and a peak duration of 2 hours. It is moderately active at a 1mg dosage, and 2mg provides a strong/heavy trip. This substance is considerably less potent when compared to the more popular NBOMes such as 25B-NBOMe, 25I-NBOMe, and 25C-NBOMe, all of which lead to strong trips at 1mg+ doses.
In terms of its chemistry, 25N-NBOMe is a substituted phenethylamine with methoxy groups attached to carbons R2 and R5 as well as a nitrophenyl group attached to carbon R4. It differs from 2C-N structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group, which in turn increases potency about a hundred fold.
In terms of its pharmacology, 25N-NBOMe has efficacy at the 5-HT2A receptor where it is assumed to act as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. There is insufficient scientific research to determine this compound’s true nature as the pharmacological properties of 25N-NBOMe have not been described in the literature but only in anecdotal reports. 25N-NBOMe has been sold as a street drug and has only been described in the literature in terms of identification by forensic analysis.
|Threshold||< 100 µg|
|Light||100 – 300 µg|
|Common||300 – 800 µg|
|Strong||800 – 1300 μg|
|Heavy||The NBOMe series can be fatal when insufflated. It is strongly discouraged.|
|Total||4 – 8 hours|
|Offset||2 – 3 hours|
|After effects||5 – 10 hours|
25N-NBOMe or 2C-N-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-N. It is a substituted phenethylamine with methoxy groups CH3O- attached to carbons R2 and R5 as well as a nitro group NO2– attached to carbon R4. It differs from 2C-N structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image to the right. 25N-NBOMe shares this 2-methoxybenzyl substitution with other chemicals of the NBOMe family. This NBOMe addition contains a methoxy ether CH3O- bound to a benzene ring at R2.
The toxicity and long-term health effects of recreational 25N-NBOMe use have not been studied in any scientific context and the exact toxic dosage is unknown. This is because 25N-NBOMe is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 25N-NBOMe suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed).
Users should be very careful and consider that ingesting 2mg+ of NBOMe series chemicals have proven fatal in some cases. Although there are no reported deaths caused by 25N-NBOMe at this time, it is a rare research chemical with very little history of human usage and is therefore potentially fatal at heavy dosages.
It is strongly recommended that one use harm reduction practices when using this drug.
25N-NBOMe is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Almost immediately after ingestion tolerance occurs, mainly to the effects of 25N-NBOMe. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 25N-NBOMe presents cross-tolerance with all psychedelics, meaning that after the consumption of 25N-NBOMe all psychedelics will have a reduced effect.
There is a extremely small margin between a normal dose or an overdose, because of the very high potency and seemingly unpredictable effects. Specifically NBOMe compounds are subject to this small margin. The exact toxic dose is unclear since it seems to depend a lot on personal physiology, rather than predominantly dosage, but various anecdotal reports suggest dangerous side effects start to show up when exceeding 1000 μg and it possibly becoming lethal for the more sensitive people at roughly 2000 μg. Reports of other people surviving much higher doses, sometimes even without any major side effects has been documented as well. There is also the uncertainty of dosage on blotter paper since it is rather difficult to lay such an exact dosage. Insufflating, vaporizing or drinking tinctures of this substance is highly discouraged because of this and has been tied to many documented deaths.
The overdose effects of NBOMes are typically a dangerously high heart rate, blood pressure, hyperthermia and significant vasoconstriction also accompanied by confusion, delusions, panic attacks, aggressive behavior, numbness or pain, amnesia and often seizures. The risks in an overdose include anything from organ failure to cardiac arrest and death. There are also multiple reports of people lethally injuring themselves or falling to death. Benzodiazepines or antipsychotics can help with the psychological effects during an overdose although medical attention should always be called in even a possible overdose of 25I-NBOMe.
What are NBOMes?
NBOMes is the name for a series of drugs that have hallucinogenic effects. Reports indicate that there are a number of different versions of NBOMe available – all with differing effects. Likewise, psychedelics change the way a person perceives the world and can affect all the senses, altering a person’s thinking, sense of time and emotions.
What do they look like?
NBOMes can be in the form of blotting paper (similar to LSD) with images and logos from popular culture, clear liquid, white powder or a pill. NBOMes have a very bitter taste whereas LSD has no taste.
Effects of NBOMes
There is no safe level of drug use. Use of any drug always carries some risk – even prescribed medications can produce unwanted side effects.
Low to moderate doses of NBOMes can produce effects that last between 4 – 10 hours.
NBOMes affects everyone differently, but reported effects have included:
- seeing and hearing things that aren’t there
- feeling happy and relaxed
- heightened senses (sight, hearing and touch)
- increased sex drive
- feelings of empathy
- large pupils
- memory lapses
- small increase in heart rate.
If you take a large amount or have a strong batch, you might overdose. Because of that, you should call an ambulance straight away by dialling triple zero (000) if you have any of these symptoms (ambulance officers don’t need to involve the police):
- difficulty communicating
- restless sleep and exhaustion
- paranoia, fear and panic
- agitation and aggression
- spasms in the eye
- rapid heart rate
- blue fingers and toes
There have also been reports of deaths as a result of car accidents, suicide and drownings.
Using an NBOMe carries a high risk of overdose due to the small difference between the amount required to produce a high and that which causes overdose. Not knowing the amount contained in the tablet or blotter increases the risk of overdose as it’s easy to take too much.
Taking an NBOMe with other drugs
The effects of mixing an NBOMe with other drugs, including alcohol, prescription medication and over-the-counter medicines are not known. However, reports of people attending emergency departments after taking an NBOMe demonstrate that alcohol and other drugs may contribute to overdose effects.