3,4-CTMP crystal rocks – More information
3,4-Dichloromethylphenidate (also known by the incorrectly abbreviated name 3,4-CTMP) is a stimulant substance of the phenidate class. It is a structural analog of methylphenidate (Ritalin). The two substances have similar pharmacological profiles but different subjective effects.
It is approximately seven times more potent than methylphenidate in animal studies, but likely has weaker reinforcing effects due to its slower onset of action. According to anecdotal reports, the active dose of 3,4-CTMP is approximately 10 times lower than the dose of methylphenidate to achieve a similar effect. 3,4-CTMP has a duration of 6 to 18 hours rather than the 4 to 6 hour duration found with methylphenidate.
Due to its potent stimulant effects, habit-forming properties as well as an unknown toxicity profile, it is strongly recommended that one use proper harm reduction practices if using with this substance.
|Systematic name||Methyl 2-(3,4-dichlorophenyl)-2-(piperidin-2-yl)acetate|
|Chemical class||Phenidate / Piperidine|
3,4-CTMP dosage table
|Threshold||< 2 mg|
|Light||2 – 4 mg|
|Common||4 – 6 mg|
|Heavy||6 mg +|
3,4-CTMP effect progress
|Total||6 – 18 hours|
|After effects||2 – 24 hours|
3,4-CTMP, or 3,4-dichloromethylphenidate, is a synthetic molecule of the substituted phenethylamine class. It contains a phenethylamine core featuring a phenyl ring bound to an amino -NH2 group through an ethyl chain. It is structurally similar to amphetamine, featuring a substitution at Rα which is incorporated into a piperidine ring ending at the terminal amine of the phenethylamine chain. Additionally, it contains a methyl acetate bound to R2 of its structure and is chlorinated at R3 and R4 of its phenyl ring.
3,4-CTMP is nearly identical in structure to methylphenidate; the difference is that it contains two chlorine atoms bonded to the phenyl group at the 3 and 4 positions.
The toxicity and long-term health effects of recreational 3,4-CTMP use do not seem to have been studied in any scientific context, and the exact toxic dosage is unknown. This is because 3,4-CTMP is a research chemical with very little history of human usage.
Although anecdotal evidence from people who have tried 3,4-CTMP suggests that there are unlikely to be negative health effects attributed to simply trying the substance by itself at low to moderate doses, the agonist activity it displays for the 5-HT2B receptor is a cause for concern, as acute 5-HT2B agonism has been shown to result in a potentially dangerous and largely asymptomatic effect called pulmonary hypertension. Moreover, the long-term stimulation of 5-HT2B receptors has been shown to lead to fibrosis of the heart valves, which may result in stroke and/or severe, permanent heart disease.
Other substances that display this activity, such as the recalled weight-loss drug aminorex, have caused serious and often fatal heart disease when used for even relatively short periods of time. It is highly recommended that, should one choose to use this substance despite these concerns, it only be taken very sparingly and in low doses.
Those with cardiovascular diseases of any kind should not consume this substance. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Extreme caution must be taken when managing one’s 3,4-CTMP usage as the duration of its stimulating effects can be very long, which can cause unwanted sleep inhibition. This should be considered when redosing as the physically stimulating effects of a dose may persist after the psychological effects have worn off. A user attempting to maintain a state of euphoria may run the risk of accumulating medically dangerous quantities of the substance in their bloodstream.
It is strongly recommended that one not insufflate 3,4-CTMP as it has a low solubility in water so is not readily absorbed through the nasal mucus membrane and anecdotal reports suggest that insufflation of the substance is painful and potentially extremely caustic. Additionally, the poor adsorption by the nasal mucus membrane often results in the majority of the substance slowly entering the stomach through a post-nasal drip, making the onset duration even longer, which may increase the chance of an ‘accidental overdose’ if one redoses more due to a lack of effect.
It is strongly recommended that one use harm reduction practices when choosing to use this substance.
In terms of its tolerance, many users have reported that 3,4-CTMP can be used for multiple days in a row for extended periods of time without any noticeable acute tolerance build up, instead increasing gradually over regular and extended use. Unusually, there are some reports indicating a sudden rise in tolerance after an extended period of relatively little increase. This results in the user requiring an increase in dosage to achieve the same effects or to remain functional. Increasing dose to match tolerance places one at high risk of addiction.