4-AcO-DET crystals – More information
4-AcO-DET (4-Acetoxy-N,N-diethyltryptamine, ethacetin) is an obscure synthetic psychedelic tryptamine. There is very little information on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection. Today it is either used recreationally as a designer drug or as an entheogenic compound and is typically acquired through the use of online research chemical vendors. It remains relatively rare and has very little documented history of human usage.
4-AcO-DET is the acetylated form of 4-HO-DET (also known as ethocin) and is a higher homolog of 4-AcO-DMT and 4-AcO-MET. Like the aforementioned compounds, it is commonly hypothesized to act principally as a prodrug for their respective hydrolyzed counterparts (e.g. 4-HO-DMT, 4-HO-MET and 4-HO-DET). In theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.
|Common names||4-AcO-DET, 4-Acetoxy-DET, Ethacetin|
|Systematic name||3-(2-(Diethylamino)ethyl)-1H-indol-4-yl acetate|
4-AcO-DET dosage table
|Threshold||5 – 10 mg|
|Light||10 – 15 mg|
|Common||15 – 20 mg|
|Strong||20 – 35 mg|
|Heavy||35 mg +|
4-AcO-DET effect progress
|Total||4 – 7 hours|
|Offset||1 – 2 hours|
|After effects||2 – 4 hours|
4-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−. It also contains isopropyl and methyl chains bound to the terminal amine RN of its tryptamine backbone (DET).
The toxicity and long-term health effects of recreational 4-AcO-DET has not been studied in any scientific context and the exact toxic dose is unknown.
This is because 4-AcO-DET is a research chemical with a very limited history of human usage.
However, it is assumed to have a similar toxicity profile as psilocybin due to their structural similarity.
Anecdotal reports from those who have tried 4-AcO-DET suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices when using this substance.
Although no formal studies have been conducted, it is believed that 4-AcO-DET is not habit-forming and the desire to use it can actually decrease with use.
Tolerance to the effects of 4-AcO-DET is built almost immediately after ingestion.
After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption).
4-AcO-DET presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-AcO-DET all psychedelics will have a reduced effect.
Due to its relative obscurity, the possession and sale of 4-AcO-DET is unscheduled in most countries.