4-HO-MET crystals – More information
4-Hydroxy-N-methyl-N-ethyltryptamine (also known as “colour”, methylcybin, metocin, and 4-HO-MET) is a lesser-known novel psychedelic substance of the tryptamine class.
4-HO-MET is chemically similar to Psilocin, the active ingredient in psilocybin mushrooms (“magic mushrooms”). Like other substituted tryptamines, it produces its psychedelic effects by acting on serotonin receptors in the brain.
4-HO-MET was first synthesized by Alexander Shulgin and reported in his 1997 book TiHKAL (“Tryptamines I Have Known and Loved”). Reports of human use began to surface in the late 2000s following its appearance on the online research chemicals market. It has been sold alongside other psilocybin analogues such as 4-AcO-DMT and 4-HO-MiPT.
User reports typically describe 4-HO-MET as a more recreational version of psilocybin mushrooms or psilocin (4-HO-DMT) due to its less serious headspace and greater emphasis on visual effects. Notable effects include geometric visual hallucinations, time distortion, enhanced introspection, and ego loss.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. It is assumed to have a similar risk and toxicity profile as psilocybin but there is no data to support this. It is highly advised to use harm reduction practices if using this substance.
|Common names||4-HO-MET, Metocin, Methylcybin, “Colour”|
4-HO-MET dosage table
|Light||5 – 15 mg|
|Common||15 – 25 mg|
|Strong||25 – 45 mg|
|Heavy||45 mg +|
4-HO-MET effect progress
|Total||4 – 6 hours|
|Offset||1 – 1.5 hours|
|After effects||2 – 12 hours|
4-HO-MET, or 4-hydroxy-N-ethyl-N-methyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine chemical class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-MET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains a methyl group and an ethyl chain bound to the terminal amine RN of its tryptamine backbone (MET).
4-HO-MET is a 4-hydroxy homolog of 4-AcO-MET and the N-substituted ethyl homolog of psilocin (4-HO-DMT). It is also the 4-hydroxyl analog of the base tryptamine MET.
The toxicity and long-term health effects of recreational 4-HO-MET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-MET is a research chemical with very little history of human usage. However, there are reports of very high doses leading to drug induced psychosis.
Anecdotal evidence from those who have tried 4-HO-MET suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices when using this substance.
4-HO-MET is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 4-HO-MET are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-HO-MET presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-HO-MET all psychedelics will have a reduced effect.
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