4-HO-MPT crystals

4-HO-MPT crystals – More information

4-Hydroxy-N-methyl-N-propyltryptamine (also known as 4-HO-MPT or Meprocin) is a novel synthetic psychedelic substance of the tryptamine chemical class that produces psychedelic effects when administered. It is a closely related structural analog of 4-HO-DMT (Psilocin) and other hallucinogenic tryptamines with powerful psychedelic effects.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MPT. It has no history of human use before being sold online as a research chemical in 2016. It is obscure and is either used recreationally or for research purposes.

clinical data

4-HO-MPT dosage table

4-HO-MPT effect progress

Chemistry

4-HO-MPT, or 4-hydroxy-N,N-methylpropyltryptamine, is a synthetic indole molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R₃ to an amino group via an ethyl side chain. 4-HO-MPT is substituted at R₄ of its indole heterocycle with a hydroxyl functional group OH−. It also contains a propyl and ethyl chain bound to the terminal amine R_N of its tryptamine backbone (MPT).

Toxicity

The toxicity and long-term health effects of recreational 4-HO-MPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-MPT is a research chemical with very little history of human usage.

Anecdotal evidence from people within the community who have tried it suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance

4-HO-MPT is generally considered not habit-forming and the desire to use it can actually decrease with regular consumption. Like with most psychedelics, it is most often thought to be self-regulating.

Tolerance to the effects of 4-HO-MPT are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-HO-MPT presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-HO-MPT all psychedelics will have a reduced effect.

Legality

Due to its relative obscurity, the possession and sale of 4-HO-MPT is unscheduled in most countries.

References