Prolintane crystal rocks

Prolintane crystal rocks – More information

1-Phenyl-2-pyrrolidinylpentane (also known as Prolintane or Pyrrolidinopentiophenone, and by the trade names Catovit, Promotil, and Villescon) is a synthetic central nervous system (CNS) stimulant that is structurally similar to the substituted pyrrolidine class of compounds such as MDPV and A-PVP albeit with notably attenuated effects. Prolintane was first synthesized in the 1950s, where it was found primarily to act as as a norepinephrine–dopamine reuptake inhibitor (NDRI) which is thought to confer it stimulant and potential nootropic qualities.

Historical reports show records of the preparation of prolintane for use as a mild CNS stimulant, wakefulness agent, and cessation aid for cocaine addiction. It has been marketed in Europe since the 1960s as an antidepressant (i.e. due to its anti-fatigue properties) and analeptic. It has a history of being used in neuropsychiatric research related to CNS stimulants with reduced side effects. Therapeutic uses of prolintane in Africa, Europe, and Australia include the treatment of narcolepsy, ADHD, fatigue, and orthostatic hypotension. It is not approved for pharmaceutical use in the United States.

The first reports of prolintane abuse appeared in Europe during the early 2000s when prolintane was identified in tablets distributed at a rave party. Later reports documented the recreational use of prolintane in the United States, where it appears to substitute for recreational amphetamine and other stimulant use.

clinical data

Prolintane dosage table

Prolintane effect progress

Chemistry

Prolintane, or 1-Phenyl-2-pyrrolidinylpentane, is a synthetic stimulant of the pyrrolidine class.

Toxicity

The toxicity and long-term health effects of recreational prolintane use do not seem to have been studied in any scientific context, and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried prolintane within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

Lethal dosage

The exact lethal dosage of prolintane is unknown, and no formal studies have been carried out in humans. The typical adult therapeutic dose of prolintane has been 10-40mg daily. In therapeutic trials, 20mg prolintant is a mild stimulant equivalent to 100mg caffeine. In a study of fatigued volunteers the administration of 20mg or 40mg prolintane produced similar, but less intense effects than 20mg d-amphetamine. In experimental studies of healthy volunteers, prolintane has little cardiovascular activity following the single dose of 20mg.

Tolerance

Unlike some of the other more potent stimulants in its class, the chronic use of prolintane can be considered mildly to moderately addictive with only a moderate potential for abuse and is capable of causing psychological dependence among certain users.

When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Addiction is a potential risk among users of prolintane as it can cause compulsive redosing, although typically to a far lesser degree than the notoriously compulsive cathinone analogs A-PVP and MDPV.

Psychosis

User reports indicate that chronic abuse or single overdose exposure of prolintane can potentially lead to psychosis. Psychotic symptoms from prolintane can include hearing voices, visual hallucinations, urges to harm oneself, severe anxiety, mania, grandiosity, paranoid delusions, confusion, increased aggression, and irritability.