A-PHP crystal rocks – More information
alpha-Pyrrolidinohexiophenone (also known as PV-7, alpha-PHP, A-PHP, and α-PHP) is a lesser-known novel stimulant substance of the cathinone class. It is structurally related to compounds such as MDPV and is one of the successors to the designer drug cathinone analog α-PVP.
α-PHP generally comes in the form of either a fine powder or crystallized shards which users can ingest to produce powerful but short-lived euphoric stimulant effects which are comparable to those of methamphetamine and cocaine when insufflated or vaporized. Like its research chemical cathinone predecessors, it is has gained notoriety for its tendency to induce compulsive redosing and addictive behaviors in a large percentage of its users as well the ability to readily induce delusional states and psychosis when abused.
α-PHP has a short history of use and is subject to much scrutiny by the media. It is being used and marketed as a replacement for α-PVP (known on the street as flakka) a few years following its ban, where it has come to substitute α-PVP in many parts of the world. While initially mass synthesized in Chinese industrial laboratories, a ban on α-PHP within China’s borders has forced production to nations worldwide.
Very little data exists about the pharmacological properties, metabolism, and toxicity of α-PHP. It has recently become commonly marketed alongside research chemical stimulants like NEP and Hexen as a legal, grey-market alternative to a-PVP, and commercially distributed through online research chemical vendors.
|Common names||α-PHP, alpha-PHP, PV7|
|Chemical class||Cathinone / Pyrrolidinophenone|
A-PHP dosage table
|Threshold||0.5 – 1 mg|
|Light||1 – 5 mg|
|Common||5 – 15 mg|
|Strong||15 – 25 mg|
A-PHP effect progress
|Total||2 – 5 hours|
|Offset||30 – 90 minutes|
|After effects||2 – 4 hours|
α-PHP, or α-Pyrrolidinohexanophenone, is a compound of the substituted cathinone and substituted pyrrolidine chemical classes. Its structure is comprised of hexanal bound to a phenyl ring at the 1 position and the nitrogen of a pyrrolidine ring at the 2 position.
α-PHP is the longer chain homolog of α-PVP, possessing an additional carbon on the alkyl side chain.
The toxicity and long-term health effects of recreational α-PHP use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because α-PHP has very little history of human usage. Anecdotal evidence from people who have tried α-PHP within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
α-PHP has been reported to be the cause, or a significant contributory cause, of death in suicides and overdoses caused by combinations of drugs.
It is strongly recommended that one use harm reduction practices when using this substance.
As with other short-lived highly dopaminergic stimulants, the chronic use of α-PHP can be considered highly addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Tolerance to many of the effects of α-PHP develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 – 7 days for the tolerance to be reduced to half and 1 – 2 weeks to be back at baseline (in the absence of further consumption). α-PHP presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of α-PHP all stimulants will have a reduced effect.
α-PHP, like other strongly dopaminergic stimulants, can result in a stimulant psychosis that may present with a variety of symptoms (e.g., paranoia, hallucinations, or delusions). A review on treatment for amphetamine, dextroamphetamine, and methamphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely. The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis.
Serotonin syndrome risk
Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.