PRO-LAD blotters 100 µg

PRO-LAD blotters 100 µg – More information

N-Propylnorlysergic acid N,N-diethylamide (also known as 6-Propyl-6-nor-lysergic acid diethylamide, N-PropylnorLSD or simply PRO-LAD) is a novel psychedelic substance of the lysergamide class. It is a structural analog of LSD and is part of a series of LSD analogs which includes AL-LAD and ETH-LAD.

PRO-LAD was first investigated by Andrew J. Hoffman and David E. Nichols in 1984 as part of a series of LSD analogs. It was later described as an analog of LSD by Alexander Shulgin in the book TiHKAL (“Tryptamines I Have Known and Loved”), in which one report remarks that it is “good for humor, even excellent… very good for clear thinking, although not cosmic-type particularly.” It has been sold on the online research chemical market alongside lysergamides like 1P-LSD and AL-LAD as a legal, grey-market alternative to LSD.

Subjective effects are similar to LSD and include open and closed-eye visuals, time distortion, enhanced introspection, ego loss, and euphoria. It has been reported to be around as potent as LSD itself with an active dose reported at between 100 and 200 micrograms.

Very little data exists about the pharmacological properties, metabolism, and toxicity of PRO-LAD, and it has little history of human usage. It is highly advised use harm reduction practices if using this substance.

clinical data

PRO-LAD dosage table

PRO-LAD effect progress

Chemistry

PRO-LAD, or 6-propyl-6-nor-lysergic acid diethylamide, is a semisynthetic alkaloid of the lysergamide family. PRO-LAD is a structural analog of lysergic acid, with an N,N-diethylamide functional group bound to R_N of the chemical structure. This core polycyclic structure is an ergoline derivative, and has overlapping tryptamine and phenethylamine groups embedded within it (although it is principally classed as a tryptamine).

PRO-LAD’s structure contains a bicyclic hexahydroindole fused to a bicyclic quinoline group (nor-lysergic acid). Unlike LSD, PRO-LAD does not contain a methyl group substituted at R₆ of its nor-lysergic acid skeleton, this is represented by the nor– prefix. Instead, PRO-LAD is substituted at R₆ with a propyl group. At carbon 8 of the quinoline a N,N-diethyl carboxamide is bound.

PRO-LAD is a derivative of LSD, differing by the addition of two carbons to the methyl group at R₆ of the structure to form a propyl chain. PRO-LAD is also homologous to ETH-LAD, which contains an ethyl substitution at R₆ instead of a propyl chain.

PRO-LAD is a chiral compound with two stereocenters at R₅ and R₈. PRO-LAD, also called (+)-D-PRO-LAD, has an absolute configuration of (5R, 8R).

Toxicity

The toxicity and long-term health effects of recreational PRO-LAD do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because PRO-LAD is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried PRO-LAD suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Abuse

While no formal studies have been conducted, PRO-LAD is likely not habit-forming and it is reasonable to speculate that the desire to use it can actually decrease with repeated administratino. As with most psychedelics, it likely possesses what is considered an intrinsic, self-regulating aspect to it.

Tolerance to the effects of PRO-LAD are built almost immediately after ingestion. After that, it takes about 5-7 days for the tolerance to be reduced to half and 14 days to be back at baseline (in the absence of further consumption). PRO-LAD presents cross-tolerance with all psychedelics, meaning that after the consumption of PRO-LAD all psychedelics will have a reduced effect.