TMA-6 crystal rocks – More information
2,4,6-Trimethoxyamphetamine (also known as TMA-6) is a lesser-known psychedelic substance of the amphetamine class. It has been reported to produce a complex mixture of stimulant, hallucinogenic and entactogenic effects that distinguish it from other psychedelic phenethylamine derivatives like the 2C-x or DOx series.
TMA-6 has no history of human usage prior to the 1991 publication of its synthesis and pharmacology in the book PiHKAL (“Phenethylamines I Have Known And Loved”) by Alexander Shulgin, who called it “one of the most rewarding and pleasurable of the methoxylated amphetamines”. Since then it has been regarded as a novelty in the psychedelics community and is made available for sale only rarely by clandestine laboratory operations.
In terms of its subjective effects, it is known for its lack of classic psychedelic visuals compared to other hallucinogenic phenethylamines and is known instead for its unique stimulating body-high and intoxicating headspace.
Anecdotal reports suggest that TMA-6 is unpredictable and dose-sensitive substance that can produce uncomfortable amounts of body load, nausea, overstimulation, and inconsistencies between experiences.
In modern times, TMA-6 is used rarely as a recreational drug and a putative entheogen. It has no documentation of being sold on the streets and is almost exclusively obtainable as an obscure gray area research chemical through the use of online vendors.
|Psychoactive class||Psychedelic, Stimulant|
TMA-6 dosage table
|Threshold||5 – 10 mg|
|Light||10 – 20 mg|
|Common||20 – 35 mg|
|Strong||35 – 50 mg|
|Heavy||50 mg +|
TMA-6 effect progress
|Total||10 – 16 hours|
|Offset||3 – 5 hours|
|After effects||6 – 18 hours|
TMA-6, or 2,4,6-trimethoxyamphetamine, is a molecule of the substituted amphetamine class. Amphetamines are substituted phenethylamines, being comprised of a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα. TMA-6 contains methoxy functional groups CH3O- attached to carbons R2 and R4 and R6 of the amphetamine backbone.
The toxicity and long-term health effects of recreational TMA-6 use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because TMA-6 has very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried TMA-6 suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Though largely unstudied TMA-6 is largely considered to be not habit-forming and the desire to use it can actually decrease with consumption. It is most often self-regulating.
Tolerance to the effects of TMA-6 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). TMA-6 presents cross-tolerance with all psychedelics, meaning that after the consumption of TMA-6 all psychedelics and stimulants will have a reduced effect.
Serotonin syndrome risk
Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.