Methylnaphthidate crystal rocks – More information
Methylnaphthidate (also known as HDMP-28) is a novel synthetic stimulant substance of the substituted naphthidate and piperidine chemical classes. It is a structural analog of the commonly prescribed ADHD drug methylphenidate (e.g. Ritalin, Concerta) that produces moderately stimulating effects when administered.
Like members of the phenidate class, methylnaphthidate is believed to act as a monoamine reuptake inhibitor. However, it has been reported to display distinct differences in its subjective effects by not behaving as a traditional dopaminergic stimulant. This has been speculated to owe itself to its appreciable effects on serotonin reuptake inhibition that is not observed in typical methylphenidate analogs.
Very little data exists about the pharmacological properties, metabolism, and toxicity of methylnaphthidate, and it has little history of human usage. It is sometimes commercially distributed as a grey-area research chemical by online vendors alongside other methylphenidate analogs like ethylphenidate, isopropylphenidate, and 4F-MPH. It is highly advised to approach this and poorly understood stimulant substance with the proper amount of precaution and harm reduction practices if choosing to use it.
|Common names||Methylnaphthidate, HDMP-28|
|Systematic name||Methyl (naphthalen-2-yl)(piperidin-2-yl)acetate|
|Chemical class||Naphthidate / Piperidine|
Methylnaphthidate dosage table
|Threshold||< 4 mg|
|Light||4 – 8 mg|
|Common||8 – 14 mg|
|Strong||14 – 28 mg|
|Heavy||28 mg +|
Methylnaphthidate effect progress
|Total||90 – 180 minutes|
|Offset||1 – 2 hours|
|After effects||1 – 2 hours|
The main structural differences between methylnaphthidate and methylphenidate in chemical substance is the replacement of the core phenyl ring with with a napthalene group.
The toxicity and long-term health effects of recreational methylnaphthidate use do not seem to have been studied in any scientific context and the exact toxic and lethal dosages are unknown. This is because methylnaphthidate is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried methylnaphthidate suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent researchshould always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices when using this drug.
In terms of its tolerance, methylnaphthidate can be used multiple days in a row for extended periods of time, but acute tolerance does exist and builds up gradually over repeated extended use. This results in the user requiring an increase in dosage to achieve the same effects.
While generally considered less recreational, methylnaphthidate has potential for abuse on par with that of amphetamine, cocaine or methylphenidate due to its lack of significant tolerance, euphoric effects and action upon dopamine and serotonin transporters.