Talk:Pentylone crystal rocks – More information
Pentylone (also known as βk-MBDP and methylenedioxypentedrone) is a novel stimulant–entactogen substance of the cathinone class. Pentylone is chemically related to MDPV and belongs to a group known as the substituted cathinones. Little is known about its pharmacology, although it likely produces its activity by increasing the activity of serotonin, dopamine, and norepinephrine in the brain.
Pentylone was developed in the 1960s by Boehringer Ingelheim, although it was never marketed. It appeared around 2010 as recreational research compound, it is occasionally found as an adulterant or counterfeit for MDMA.
User reports indicate that Pentylone produces a mixture of classic stimulant and entactogenic effects resembling those of MDMA, methylone and cocaine. Commonly reported effects include stimulation, disinhibition, increased libido, compulsive redosing, and euphoria. Very little is known about pentylone at this time.
Pentylone is sold online as a research chemical alongside other synthetic cathinones like ethylone and dibutylone. Due to the lack of research, it is highly advised to use harm reduction practices if using this substance.
|Pentylone, βk-MBDP, bk-MBDP, bk-methyl-K
|Stimulant / Entactogen
|Cathinone / MDxx
Talk:Pentylone dosage table
|10 – 20 mg
|20 – 40 mg
|40 – 80 mg
|80 mg +
Talk:Pentylone effect progress
|3 – 4 hours
|1 – 6 hours
History and culture
Pentylone is a synthetic cathinone. Synthetic cathinones were first synthesized in the late 1920s, starting with methcathinone and mephedrone. However, they did not find medical use due to their side effects. In the early 2000s, synthetic cathinones began to be sold in “head” shops and online as designer drugs, also known as research chemicals and “legal highs”. Their quasi-legality and ability to substitute for traditional stimulants like cocaine or amphetamine made them popular in certain demographics. Due to a history of being falsely marketed as bath salt products, they are referred in the media as “bath salts.”
The synthesis of pentylone was first described in a patent filed by Boehringer Ingelheim in 1969. It was described alongside the synthesis of other novel central nervous system stimulants including butylone, dibutylone, and ephylone. However, its pharmacological properties were not tested and it was never marketed.
Pentylone is a synthetic substance belonging to a group known as substituted cathinones. Substituted cathinones are derivatives of the naturally occurring substance cathinone, which is one of the psychoactive principles in khat (Catha edullis). Cathinone is composed of a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon.
Pentylone is close structural relative of methylone, the beta ketone analog of MDMA. Pentylone’s chemical structure consists of a cathinone core substituted with a methylenedioxy ring at R3 and R4 of the phenyl ring, a propyl group at the alpha carbon, and a methyl group at the amino group.
Pentylone is a research chemical with a very short history of human usage. Very little is known about its long-term health effects and the exact toxic dosage is unknown.
However, numerous reports of hospitalizations and overdose deaths indicate that its analogue ephylone is extremely toxic at very high dosages.
It is strongly advised to use harm reduction practices if using this substance.
The lethal dose for pentylone is currently unknown.
As with other stimulants, the chronic use of pentylone can be considered moderately addictive with a high potential for abuse. It is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects will occur if one suddenly stops their use.
Tolerance to many of the effects of pentylone develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects.
Serotonin syndrome risk
Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.
Pentylone is banned in Canada, Germany, Sweden and also in the United States and in the UK.